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Reversible Reservoirs for Radicals. A Powerful Strategy for the Construction of Carbon-Carbon Bonds
来源: 日期2019-04-01 10:31 点击:

报告题目:Reversible Reservoirs for Radicals. A Powerful Strategy for the Construction of Carbon-Carbon Bonds

人:Prof. Samir Z. Zard




Samir Z. Zard教授1955年生于尼日利亚,早年在贝鲁特美国大学学习化学(1975年因黎巴嫩内战中断学习),1978年于伦敦帝国理工学院获得学士学位,1983年于法国巴黎南部大学获博士学位,师从诺奖得主中科院外籍院士Derek Barton教授。1981年-2003年在法国国家科学研究院(CNRS)先后任助理研究员、副研究员和研究员,2000年至今在法国巴黎综合理工大学任教授。在新型自由基反应和机理研究领域取了一系列杰出的成就,并获得多项重要奖项,包括法国化学学会有机化学分会奖(1992年)、法国科学院克拉夫·勒思皮奥奖(1995年)、罗迪亚奖(2000年)、德国化学会格林雅-维帝希奖(2008年)、英国皇家化学学会高级会员(2010年)和贝鲁特美国大学荣誉博士学位(2016年)等。迄今,在国际著名学术期刊如J. Am. Chem. Soc., Angew. Chem. Int. Ed., Acc. Chem. Res., Chem. Rev., Chem. Soc. Rev.等期刊发表学术论文357篇,申请专利38项。


Radical reactions offer many of the properties desired by synthetic organicchemists, in terms of variety, mildness of conditions, and a selectivity that is oftencomplementary to that of ionic chemistry, making many protection steps superfluous.There is however one major difficulty, which derives from the propensity of radicals tointeract with themselves (dimerization, disproportionation) with extremely fast ratesthat are close to diffusion. In this talk, Prof. Zard will show that xanthates and related thiocarbonylthioderivatives allow the generation of radicals under conditions where the radicalspossess a considerably increased effective lifetime even in a concentrated medium.Intermolecular additions to un-activated alkenes, as well as a variety of reputedlydifficult radical transformations can now be easily accomplished. No metals, heavy orotherwise, are required, and the starting materials and reagents are cheap andreadily available. Complex, densely functionalized structures can be constructed in aconvergent, modular fashion. In the course of our study of the scope and limitationsof this chemistry, we have uncovered a few surprising transformations. Recentresults and some mechanistic aspects will be presented and discussed briefly.

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