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耶鲁大学Chinedum Osuji教授学术报告
来源: 日期2017-11-06 17:53 点击:

报告题目:Microfluidic microcapsule fabrication by interfacial complexation of polymers, particles and proteins

报告人:Chinedum Osuji(耶鲁大学化学与环境工程系)




Prof. Chinedum Osuji

2012-present, Chemical Engineering, Yale University, Associate Professor

2007-2012, Chemical Engineering, Yale University, Assistant Professor

2006-2007, Chemical Engineering, Yale University, Research Scientist

2002-2005, Surface Logix Inc., Brihgton MA, Senior Research Scientist

2005-2007, Harvard University, Postdoc

2003, M.I.T., Ph.D.

1996, Cornell University, B.S.

Department of Chemical and Environmental EngineeringYale University, New Haven CT 06511

Tel. (203) 432-4387 Email: chinedum.osuji@yale.edu

Prof. Osuji leads an experimental research group focused on structure and dynamics of soft matter and complex fluids. Topics of interest include structure-property relationships in ordered soft materials, directed self-assembly of block copolymers and other soft mesophases, and rheology and slow dynamics of disordered systems. He has published ~100 papers onNature Communications,PNAS,Phys. Rev. Letter,J. Am. Chem. Soc.,Adv. Mater.,Nano Letters,ACS Nano, etc.Prof. Osuji is the recipient of a CAREER award from the National Science Foundation (2008) and the 2010 Arthur Greer award of Yale College. He received an Office of Naval Research's Young Investigator award and a 3M Nontenured Faculty award in 2012. He is the 2015 recipient of the Dillon Medal of the American Physical Society and the 2015 Hendrick C. Van Ness Award. In 2016 he was the recipient of the Yale Science and Engineering Association’s Award for Advancement of Basic and Applied Science, and the Graduate School of Arts and Sciences Graduate Mentor Award.


Microcapsules are generally spherical, hollow objects with thin, solid-like surfaces or shells. They have been aggressively pursued as designed chemical constructs for biomedical and other applications which most often seek to exploit their cargo-carrying, and cargo-releasing capability. Interfacial complexation provides a facile, rapid approach for microcapsule fabrication, and is amenable to the use of a wide variety of materials. It involves the formation of a solid-like shell due to the complexation of conjugate species at the interface of an emulsion droplet. Here we describe the use of interfacial complexation with microfluidic-generated droplets to fabricate a wide variety of monodisperse microcapsules involving polymers, particles and proteins as components of microcapsule shells. A diverse range of mechanical and release properties can be accessed depending on the specific composition of the shell layer. In particular we discuss: 1) the formation of highly stiff, yet elastic shells due to the incorporation of high-modulus cellulose nanofibrils; 2) the development of robust and modularly functionalizable microcapsules using engineered globular proteins with Janus-type characteristics, specifically, the bacterial hydrophobin BslA; 3) fabrication and optically triggered release behavior of microcapsules consisting of cross-linked graphene oxide nanosheets, with IR-photothermal responsivity. The relevance of the properties of these microcapsules to various applications is highlighted.

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