讲座题目：Superparamagnetic Nanoparticles in Biology and Medicine
讲座时间：9月25日 09:00 am-10:00 am
IMPMC - Université Pierre et Marie Curie, Paris
Recent years have seen heightened applications of magnetic nanoparticles (NPs) in biomedicine. Most of these involve iron oxide nanoparticles in the superparamagnetic (SPM) state, in which the particles behave as paramagnets with a huge magnetic moment.1-6 The applications can be roughly divided into three groups: 1. Imaging using magnetic nanoparticles, where SPM NPs are used as contrast agents in magnetic resonance imaging because of their large magnetic moments in a static magnetic field. 2. Magnetic targeting for drug and gene delivery, which can be effected in a number of different ways: a) thermomagnetic activation, in which fast relaxation of SPM NPs leads to local heating and hence drug or gene release; b) Direct magnetic activation with a rotating magnetic field; and c) magnetic guiding to critical locations with an strong external magnetic field. 3. Hyperthermia therapy, which, between 40 and 43° C, stimulates the immune system of the patient for an anticancer response, generally associated with radiotherapy or chemotherapy. In this talk I will briefly summarize progress in these areas and proceed to a more detailed discussion of two avenues recently explored.
1) K. Hervé, et al Nanotechnology 19, 465608 (2008).
2) K. Kaaki, et al Langmuir 28, 1496 (2012).
3) J. Gautier, et al Int. J. Pharm. 423, 16.(2012).
4) I. Milosevic, et al Appl. Phys. Letters 104, 043701 (2014); T. Marin et al Appl. Phys. Letters 106 , 183706 (2015)
5) H. Khurshid et al, Scientific Reports, Scientific Reports, 5, 15054, 2015
6) I. Milosevic, et al, Biochemica et BioPhysica Acta General Subjects, in press
Marie-Louise Saboungi is Distinguished Professor of Physics of the French Universities and shares her research in condensed matter physics between the University of Orleans, the CNRS and the Pierre et Marie Curie University in Paris. She served as Director of a research institute under the auspices of the CNRS and the University of Orleans for 10 years, as Co-Director of the Materials, Energy and Geosciences Thrust Area at University of Orleans for five years and as a Research and Education Minister nominee of the National Committee for the promotion of the Associate and Assistant Professors of the French Universities. Prior to that she was a Senior Scientist at Argonne National Laboratory, where she established close collaborations with the University of Chicago’s James Franck Institute and with Cornell University’s Food Sciences Department. She has over 270 publications, 5 patents and directed the work of 14 PhD candidates. She is a Fellow of the American Association for the Advancement of Science, the American Physical Society and the Alexander von Humboldt Foundation, from which she received the Helmholtz-Humboldt Prize in 2008. She has served on international advisory committees as well as national committees in the U.S. for the Department of Energy and the National Science Foundation, in France for the CNRS, ANR and AERES, and in the European Community where she is a member of the Advisory Board of the FET-Horizon 2020